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How to approach systematic literature review.manual or automated tools?

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Active 480 pts 0 followers
University of Mysore · Posted
Astronomy & Astrophysics Robotics & Automation Chemistry

Problem statement

I am working on a bioinformatics project analyzing GWAS data for a rare Indian genetic disorder. My sample size is only n=89 cases and n=143 controls due to the rarity of the condition.

Specific questions:

  1. Should I report power analysis even though I know the study is underpowered?
  2. Bonferroni seems too conservative with this sample size; is FDR acceptable?
  3. I don't have an independent cohort to validate. Is this a dealbreaker for journal submission?

This is a legitimate clinical study with IRB approval. I just want to know how to frame the limitations honestly.

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2 Replies

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Sowmya Narayanan Active 310 pts · Accepted answer

If you are not already using a reading group format with your students, I would strongly recommend it. Forces everyone to articulate what they read.

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Admin NITK · Accepted answer

Check whether your institution has a Springer/Elsevier waiver agreement.many NITs and IITs do.