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How do I convert my MTech thesis into a publishable journal paper? (85)

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Manipal Academy of Higher Education · Posted
Machine Learning & AI

Problem statement

I am working on a bioinformatics project analyzing GWAS data for a rare Indian genetic disorder. My sample size is only n=89 cases and n=143 controls due to the rarity of the condition.

Specific questions:

  1. Should I report power analysis even though I know the study is underpowered?
  2. Bonferroni seems too conservative with this sample size; is FDR acceptable?
  3. I don't have an independent cohort to validate. Is this a dealbreaker for journal submission?

This is a legitimate clinical study with IRB approval. I just want to know how to frame the limitations honestly.

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Rohan Desai Distinguished 950 pts · Accepted answer

This is exactly what I needed to hear. One clarifying question: you mentioned FedProx handles non-IID data better.does that mean I should switch to FedProx by default, or only if I observe poor convergence with FedAvg first?

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Priya Nair · Accepted answer

Overleaf + GitHub integration is underrated. You get version control and collaboration in one place.