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Should I file a patent before submitting a paper, or after? (82)

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Distinguished 950 pts 0 followers
National Institute of Technology Karnataka · Posted

Problem statement

I am working on a bioinformatics project analyzing GWAS data for a rare Indian genetic disorder. My sample size is only n=89 cases and n=143 controls due to the rarity of the condition.

Specific questions:

  1. Should I report power analysis even though I know the study is underpowered?
  2. Bonferroni seems too conservative with this sample size; is FDR acceptable?
  3. I don't have an independent cohort to validate. Is this a dealbreaker for journal submission?

This is a legitimate clinical study with IRB approval. I just want to know how to frame the limitations honestly.

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25 Replies

0
Indira Balan · Accepted answer

This question comes up a lot. The answer really depends on your specific field and what your committee values.

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Bhavana Reddy Starting 30 pts · Accepted answer

Overleaf + GitHub integration is underrated. You get version control and collaboration in one place.

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Nandita Ghosh Distinguished 720 pts · Accepted answer

As a senior faculty member (25 years in the system), I want to offer a different perspective. Yes, the pressures are real. But I have also seen the other side: students who produce excellent work, publish honestly, and build reputations over time. The system is imperfect but not entirely broken.

What has actually helped my students: choosing venues carefully (a few strong papers rather than many weak ones), developing genuine collaborations rather than transactional coauthorships.

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Kavitha Subramanian Active 365 pts · Accepted answer

Great question.I went through something very similar in my second year.

The key insight for me was that LoRA is actually quite well-suited for NER tasks, especially in low-resource settings. I would recommend:

  1. Use LoRA with r=8 or r=16.don't go higher for 8K samples
  2. Apply LoRA to attention layers only, not the feed-forward layers
  3. Use a cosine learning rate schedule with warm-up (10% of steps)

For Telugu-English code-mixed NER specifically, you might also look at MuRIL.it is pretrained on Indian language data and often outperforms XLM-R on Indic tasks even with less fine-tuning data.

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Revathi Chandrasekaran Active 410 pts · Accepted answer

Strongly agree with the point about choosing venues carefully. One paper in NeurIPS > five papers in obscure workshops.

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Rekha Shetty Starting 40 pts · Accepted answer

Just to make sure I understand the Zotero workflow correctly.is the .bib file synced to Overleaf automatically every time you add a new paper, or do you need to trigger an export manually?

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Rekha Shetty Starting 40 pts · Accepted answer

Highly recommend checking out the PMRF portal for the actual numbers.they update the stipend structure annually.

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Manish Tiwari Starting 10 pts · Accepted answer

I have a slightly different take from my experience in industry research. The reproducibility crisis is real but unevenly distributed. Fields with strong engineering culture (computational biology, ML with benchmarks) have actually improved significantly in the last 5 years. The bigger problem is in fields where data sharing is structurally difficult.clinical medicine, behavioral economics.

The ML community's move toward open code and reproducibility checklists has been genuinely effective.

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Geeta Rao · Accepted answer

I have a slightly different take from my experience in industry research. The reproducibility crisis is real but unevenly distributed. Fields with strong engineering culture (computational biology, ML with benchmarks) have actually improved significantly in the last 5 years. The bigger problem is in fields where data sharing is structurally difficult.clinical medicine, behavioral economics.

The ML community's move toward open code and reproducibility checklists has been genuinely effective.

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Karthik Rajan Growing 180 pts · Accepted answer

Overleaf + GitHub integration is underrated. You get version control and collaboration in one place.

0
Sanjay Kumar Growing 145 pts · Accepted answer

I found that writing a paper abstract first (before the paper) and then reverse-engineering the paper from the abstract helped with clarity enormously.

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Amit Joshi Starting 15 pts · Accepted answer

This is really helpful context. One more question: for the ethics committee approval, does the institution where the data is collected or the institution where the analysis is performed need to be the primary ethics approver?

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Replying to Amit Joshi
Manish Tiwari Starting 10 pts · Accepted answer

Thank you! The reference to MuRIL is particularly useful.I had not considered it as an alternative to XLM-R for Indic languages.

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Nandita Ghosh Distinguished 720 pts · Accepted answer

Thank you for this detailed answer! A quick follow-up: when you mention cosine learning rate with warm-up, are you warming up the LoRA parameters specifically or the entire model including the frozen backbone?

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Divya Krishnan Growing 85 pts · Accepted answer

I can answer your question about IEEE Transactions review timelines from my experience submitting to IEEE TNNLS.

For Q1 IEEE journals, expect:

  • Initial desk review: 2–4 weeks
  • Full peer review: 3–6 months
  • Major revision decision: another 2–3 months for re-review

As for code and data, most IEEE journals now request code upon acceptance, not submission. Regarding your 2.3% improvement.that is borderline. You will need very strong experimental rigor: multiple runs, confidence intervals, and significance tests.

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Replying to Divya Krishnan
Divya Krishnan Growing 85 pts · Accepted answer

Open access is the right direction but the APCs are prohibitively expensive for many Indian researchers without institutional funding.

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Xena D'Souza Starting 25 pts · Accepted answer

Great question.I went through something very similar in my second year.

The key insight for me was that LoRA is actually quite well-suited for NER tasks, especially in low-resource settings. I would recommend:

  1. Use LoRA with r=8 or r=16.don't go higher for 8K samples
  2. Apply LoRA to attention layers only, not the feed-forward layers
  3. Use a cosine learning rate schedule with warm-up (10% of steps)

For Telugu-English code-mixed NER specifically, you might also look at MuRIL.it is pretrained on Indian language data and often outperforms XLM-R on Indic tasks even with less fine-tuning data.

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Jagdish Rawat · Accepted answer

FDR (Benjamini-Hochberg) is widely accepted and preferable to Bonferroni when you have many tests and limited power. The key is to be explicit about which correction you used and why.

On replication: No independent cohort is a genuine limitation but not a dealbreaker for rare disease research, where cohort availability is a known constraint. Many high-quality papers acknowledge this and still get published in good journals. Frame it as future work.

Power analysis: Yes, report it. Showing you are aware of the limitation is better than not mentioning it.

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Replying to Jagdish Rawat
Ishaan Verma Growing 60 pts · Accepted answer

For longitudinal data with missing values, mixed-effects models handle this more gracefully than imputation in most cases.

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Replying to Jagdish Rawat
Ravi Patel Starting 25 pts · Accepted answer

+1 to everything said above. My experience was identical.

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Revathi Chandrasekaran Active 410 pts · Accepted answer

Strongly agree with the point about choosing venues carefully. One paper in NeurIPS > five papers in obscure workshops.

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Neha Agarwal Growing 90 pts · Accepted answer

Strongly agree with the point about choosing venues carefully. One paper in NeurIPS > five papers in obscure workshops.

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Aditya Sharma Starting 45 pts · Accepted answer

For longitudinal data with missing values, mixed-effects models handle this more gracefully than imputation in most cases.

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Replying to Aditya Sharma
Prakash Iyer Distinguished 640 pts · Accepted answer

Thank you! The reference to MuRIL is particularly useful.I had not considered it as an alternative to XLM-R for Indic languages.

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Farhan Mirza · Accepted answer

Just to make sure I understand the Zotero workflow correctly.is the .bib file synced to Overleaf automatically every time you add a new paper, or do you need to trigger an export manually?