Problem statement
I am working on a bioinformatics project analyzing GWAS data for a rare Indian genetic disorder. My sample size is only n=89 cases and n=143 controls due to the rarity of the condition.
Specific questions:
- Should I report power analysis even though I know the study is underpowered?
- Bonferroni seems too conservative with this sample size; is FDR acceptable?
- I don't have an independent cohort to validate. Is this a dealbreaker for journal submission?
This is a legitimate clinical study with IRB approval. I just want to know how to frame the limitations honestly.